Roberto Martínez called 26 players, but Nelson Semedo, Pepe, Diogo Dalot and Rafael Leão ended up unable to join the training camp, with Raphael Guerreiro, a returnee, and João Mário, from FC Porto, a debutant, being included in the line up.
With qualification and first place in the group guaranteed, the mountainous setting of Vaduz is the location for Portugal to add their ninth victory in nine games and be able to say goodbye in perfect fashion on Sunday against Iceland, at the José Alvalade Stadium, in Lisbon.
As has been customary, Roberto Martínez made few new additions to the squad list, with Bruma being the only surprise and having the opportunity, at this stage, to show his value to the Spanish coach.
Faced with the last placed team in Group J, with zero points and a record of one goal scored and 25 conceded, the only doubt seems to be the size of the win that Portugal will impose against its rival.
Liechtenstein-Portugal is scheduled for 20:45 (19:45 in Lisbon) and will be refereed by the Swedish Mohammed Al-Hakim.
Portugal leads Group J with 24 points, eight more than Slovakia, second placed, with Luxembourg, third, with 11. Iceland is fourth, with 10 points, ahead of Bosnia-Herzegovina, with nine, and from Liechtenstein, last, without any point.